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  • 产品名称：anti-NPC2antibody(Niemann-PickDisease,TypeC2)(AA22-149)

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  • 产品厂商：SXBIO
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简单介绍：
anti-NPC2antibody(Niemann-PickDisease,TypeC2)(AA22-149)
详情介绍：
Immunogen Recombinant dog Epididymal secretory protein E1 protein(22-149aa)
Isotype IgG
Purification Caprylic Acid Ammonium Sulfate Precipitation purified
Alternative Name Epididymal Secretory Protein E1 (NPC2 Antibody Abstract)
Background Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
UniProt Q28895
Restrictions For Research Use only
Format Liquid
Buffer Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C/-80 °C