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  • 产品名称：anti-MetalloproteinaseInhibitor2(TIMP2)(AA27-221)antibody

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简单介绍：
anti-MetalloproteinaseInhibitor2(TIMP2)(AA27-221)antibody
详情介绍：
Immunogen TIMP2 (AAH52605, 27 a.a. ~ 221 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5B11
Isotype IgG2a kappa
Specificity TIMP2 (AAH52605, 27 a.a. ~ 221 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TIMP2 (TIMP2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 24399 DA
Gene ID 12406
Research Area Cell Cycle, Cell Structure
Pathways cAMP Metabolic Process
Comment

Background: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-221) antibody (ABIN396528) Immunofluorescence of monoclonal antibody to TIMP2 on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-221) antibody (ABIN396528) anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-221) antibody (Image 2)
Background publications Roder, Peters, Kasuya, Nishizawa, Takehara, Berg, Schulte, Khan, Tatagiba, Krischek: "Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans." in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, Vol. 27, Issue 2, pp. 245-52, 2011 (PubMed).

Alakus, Afriani, Warnecke-Eberz, Bollschweiler, Fetzner, Drebber, Metzger, H?lscher, M?nig: "Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer." in: World journal of surgery, Vol. 34, Issue 12, pp. 2853-9, 2010 (PubMed).

Yeh, Cheng, Chang, Yang, Sheu: "Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females." in: BMC microbiology, Vol. 10, pp. 218, 2010 (PubMed).

Romero, Friel, Velez Edwards, Kusanovic, Hassan, Mazaki-Tovi, Vaisbuch, Kim, Erez, Chaiworapongsa, Pearce, Bartlett, Salisbury, Anant, Vovis, Lee, Gomez, Behnke, Oyarzun, Tromp, Williams, Menon: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Nikopensius, Jagom?gi, Krjutskov, Tammekivi, Saag, Prane, Piekuse, Akota, Barkane, Krumina, Ambrozaityte, Matuleviciene, Kucinskiene, Lace, Kucinskas, Metspalu: "Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 9, pp. 748-56, 2010 (PubMed).