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  • 产品名称：anti-APOBEC3Aantibody(ApolipoproteinBMRNAEditingEnzyme,CatalyticPolypeptide-Lik

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  • 产品厂商：半导体
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简单介绍：
anti-APOBEC3Aantibody(ApolipoproteinBMRNAEditingEnzyme,CatalyticPolypeptide-Like3A)(AA20-49)
详情介绍：
Immunogen This APOBEC3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human APOBEC3A.
Clone RB42401
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name APOBEC3A (APOBEC3A Antibody Abstract)
Background This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. One allele of this gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3A, and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B.

Synonyms: APOBEC3A, Probable DNA dC->dU-editing enzyme APOBEC-3A, Phorbolin-1
NCBI Accession NP_001180218, NP_663745
UniProt P31941
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A) (AA 20-49), (N-Term) antibody (ABIN1881066) APOBEC3A Antibody (N-term) (ABIN1881066) western blot analysis in ZR-75-1 cell line l...
Product cited in: Thielen, McNevin, McElrath, Hunt, Klein, Lingappa: "Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27753-66, 2010 (PubMed).

Berger, Münk, Schweizer, Cichutek, Schüle, Flory: "Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12248-54, 2010 (PubMed).

Stenglein, Burns, Li, Lengyel, Harris: "APOBEC3 proteins mediate the clearance of foreign DNA from human cells." in: Nature structural & molecular biology, Vol. 17, Issue 2, pp. 222-9, 2010 (PubMed).

Abe, Ochi, Maekawa, Hatakeyama, Tsuge, Kitamura, Kimura, Miki, Mitsui, Hiraga, Imamura, Fujimoto, Takahashi, Nakamura, Kumada, Chayama: "Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 39, Issue 12, pp. 1159-68, 2009 (PubMed).

Prochnow, Bransteitter, Chen: "APOBEC deaminases-mutases with defensive roles for immunity." in: Science in China. Series C, Life sciences / Chinese Academy of Sciences, Vol. 52, Issue 10, pp. 893-902, 2009 (PubMed).