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  • 产品名称：anti-TXNIPantibody(ThioredoxinInteractingProtein)(AA116-145)

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简单介绍：
anti-TXNIPantibody(ThioredoxinInteractingProtein)(AA116-145)
详情介绍：
Immunogen This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.
Clone RB30652
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Txnip (TXNIP Antibody Abstract)
Background May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Synonyms: Txnip, Vdup1, Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1
NCBI Accession NP_001009935, NP_076208
UniProt Q8BG60
Pathways Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.46 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Thioredoxin Interacting Protein (TXNIP) (AA 116-145), (Center) antibody (ABIN1881961) Mouse Txnip Antibody (Center) (ABIN1881961) western blot analysis in mouse stomach ti...
Product cited in: Martin: "[Growing old]." in: Revue médicale suisse, Vol. 6, Issue 256, pp. 1424, 2010 (PubMed).

Kwon, Lim, Han, Lee, Yoon, Nam, Choi, Kim, Won, Kim: "The role of vitamin D3 upregulated protein 1 in thioacetamide-induced mouse hepatotoxicity." in: Toxicology and applied pharmacology, Vol. 248, Issue 3, pp. 277-84, 2010 (PubMed).

Kwon, Won, Suh, Jeon, Shao, Yoon, Chung, Kim, Kim, Nam, Yoon, Kim, Kim, Kim, Kim, Kim, Choi: "Vitamin D3 upregulated protein 1 suppresses TNF-?-induced NF-?B activation in hepatocarcinogenesis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 3980-9, 2010 (PubMed).

Ren, Shi, Wang, Li, Wu, Li, Zhang, Duan: "p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells." in: FEBS letters, Vol. 584, Issue 15, pp. 3480-5, 2010 (PubMed).

Shao, Kim, Shin, Kim, Suh, Piao, Jeong, Lee, Yoon, Lim, Kim, Ahn, Choi: "TXNIP regulates germinal center generation by suppressing BCL-6 expression." in: Immunology letters, Vol. 129, Issue 2, pp. 78-84, 2010 (PubMed).