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  • 产品名称：anti-TXNIPantibody(ThioredoxinInteractingProtein)(AA1-30)

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  • 产品厂商：半导体
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简单介绍：
anti-TXNIPantibody(ThioredoxinInteractingProtein)(AA1-30)
详情介绍：
Immunogen This TXNIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TXNIP.
Clone RB41554
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name TXNIP (TXNIP Antibody Abstract)
Background TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Synonyms: TXNIP, VDUP1, Thioredoxin-interacting protein, Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1
NCBI Accession NP_006463
UniProt Q9H3M7
Pathways Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Thioredoxin Interacting Protein (TXNIP) (AA 1-30), (N-Term) antibody (ABIN1881962) TXNIP Antibody (N-term) (ABIN1881962) western blot analysis in NCI-H292 cell line lys...
Product cited in: Zhuo, Niu, Chen, Xin, Guo, Mao: "Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31491-501, 2010 (PubMed).

Kwon, Won, Suh, Jeon, Shao, Yoon, Chung, Kim, Kim, Nam, Yoon, Kim, Kim, Kim, Kim, Kim, Choi: "Vitamin D3 upregulated protein 1 suppresses TNF-?-induced NF-?B activation in hepatocarcinogenesis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 3980-9, 2010 (PubMed).

Yu, Chai, He, Hagen, Luo: "Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25822-30, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).