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  • 产品名称：anti-AuroraKinaseCantibody(AURKC)(AA3-38)

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简单介绍：
anti-AuroraKinaseCantibody(AURKC)(AA3-38)
详情介绍：
Immunogen This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-38 amino acids from the N-terminal region of human Aurora-C.
Clone RB6507
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Aurora-C (AURKC Antibody Abstract)
Background Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.

Synonyms: AURKC, AIE2, AIK3, AIRK3, ARK3, STK13, Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C
NCBI Accession NP_003151, NP_001015879, NP_001015878
UniProt Q9UQB9
Pathways Cell Division Cycle, Maintenance of Protein Location
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Aurora Kinase C (AURKC) (AA 3-38), (N-Term) antibody (ABIN1882164) The anti-Aurora C Pab (ABIN1882164) is used in Western blot to detect Aurora C in lys...
Western Blotting (WB) image for anti-Aurora Kinase C (AURKC) (AA 3-38), (N-Term) antibody (ABIN1882164) The anti-Aurora C Pab (ABIN1882164) is used in Western blot to detect Aurora C in lys...
Product cited in: Kimura, Matsuda, Yoshioka, Okano: "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7334-40, 1999 (PubMed).

Tseng, Chen, Hsu, Tang: "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators." in: DNA and cell biology, Vol. 17, Issue 10, pp. 823-33, 1998 (PubMed).

Bernard, Sanseau, Henry, Couturier, Prigent: "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter." in: Genomics, Vol. 53, Issue 3, pp. 406-9, 1998 (PubMed).