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  • 产品名称：anti-MLLT10antibody(ProteinAF-10)(AA294-323)

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简单介绍：
anti-MLLT10antibody(ProteinAF-10)(AA294-323)
详情介绍：
Immunogen This MLLT10 (AF10) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the Central region of human MLLT10 (AF10).
Clone RB8383
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name MLLT10 (AF10) (MLLT10 Antibody Abstract)
Background Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10,11)(p12,q23) translocations. In an analysis of two leukemia patients, the in t(10,11)(p12,q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t(10,11)(p12,q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10. The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma. GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription. Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.

Synonyms: MLLT10, AF10, Protein AF-10, ALL1-fused gene from chromosome 10 protein
NCBI Accession NP_004632, NP_001182559, NP_001182557, NP_001182556, NP_001182555
UniProt P55197
Application Notes WB: 1:1000,IF: 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Immunofluorescence (IF) image for anti-Protein AF-10 (MLLT10) (AA 294-323), (Center) antibody (ABIN1882102) Western blot analysis of MLLT10 (ABIN1882102) in K562 cell line lysates (35 µg/lane)....
Western Blotting (WB) image for anti-Protein AF-10 (MLLT10) (AA 294-323), (Center) antibody (ABIN1882102) Western blot analysis of MLLT10 (ABIN1882102) in K562 cell line lysates (35 µg/lane)....
Product cited in: Benedikt, Baltruschat, Scholz, Bursen, Arrey, Meyer, Varagnolo, Müller, Karas, Dingermann, Marschalek: "The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures." in: Leukemia, Vol. 25, Issue 1, pp. 135-44, 2011 (PubMed).

Cai, Gao, Sheng, Miao, Cui, Wang, Zong, Koide: "Characterization and potential function of a novel testis-specific nucleoporin BS-63." in: Molecular reproduction and development, Vol. 61, Issue 1, pp. 126-34, 2002 (PubMed).

Perrin, Bloyer, Ferraz, Agrawal, Sinha, Dura: "The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 119-30, 2002 (PubMed).

Roll, Zattara-Cannoni, Bustos-Bernard, Curtillet, Michel, Vagner-Capodano: "Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia." in: Cancer genetics and cytogenetics, Vol. 135, Issue 2, pp. 187-91, 2002 (PubMed).

Nakamura, Mori, Tada, Krajewski, Rozovskaia, Wassell, Dubois, Mazo, Croce, Canaani: "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation." in: Molecular cell, Vol. 10, Issue 5, pp. 1119-28, 2002 (PubMed).

Debernardi, Bassini, Jones, Chaplin, Linder, de Bruijn, Meese, Young: "The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex." in: Blood, Vol. 99, Issue 1, pp. 275-81, 2001 (PubMed).