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  • 产品名称：anti-ZincFingerandBTBDomainContaining7B(ZBTB7B)(AA440-469),(C-Term)antibody

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简单介绍：
anti-ZincFingerandBTBDomainContaining7B(ZBTB7B)(AA440-469),(C-Term)antibody
详情介绍：
Immunogen This ZBTB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-469 amino acids from the C-terminal region of human ZBTB7B.
Clone RB13260
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name ZBTB7B (ZBTB7B Antibody Abstract)
Background ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.

Synonyms: ZBTB7B, ZBTB15, ZFP67, ZNF857B, Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zinc finger protein 857B, Zinc finger protein Th-POK
NCBI Accession NP_001243384, NP_001239335
UniProt O15156
Application Notes WB: 1:1000,IF: 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Immunofluorescence (IF) image for anti-Zinc Finger and BTB Domain Containing 7B (ZBTB7B) (AA 440-469), (C-Term) antibody (ABIN1882155) Western blot analysis of ZBTB7B Antibody (C-term) (ABIN1882155) in 293 cell line lysa...
Western Blotting (WB) image for anti-Zinc Finger and BTB Domain Containing 7B (ZBTB7B) (AA 440-469), (C-Term) antibody (ABIN1882155) Western blot analysis of ZBTB7B Antibody (C-term) (ABIN1882155) in 293 cell line lysa...
Product cited in: Matsumoto, Horiike, Ohshiro, Yamamoto, Sasaki, Tsutsumi, Kobayashi, Shimizu, Uchiyama, Kuroda, Nomura, Shimazaki, Taniwaki: "Expression of master regulators of helper T-cell differentiation in peripheral T-cell lymphoma, not otherwise specified, by immunohistochemical analysis." in: American journal of clinical pathology, Vol. 133, Issue 2, pp. 281-90, 2010 (PubMed).

Galéra, Musso, Ducy, Karsenty: "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 20, pp. 9372-6, 1994 (PubMed).