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  • 产品名称：anti-MAP2K2antibody(Mitogen-ActivatedProteinKinaseKinase2)(AA1-30)

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简单介绍：
anti-MAP2K2antibody(Mitogen-ActivatedProteinKinaseKinase2)(AA1-30)
详情介绍：
Immunogen This MEK2 (MAP2K2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MEK2 (MAP2K2).
Clone RB3595
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name MEK2 (MAP2K2) (MAP2K2 Antibody Abstract)
Background MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.

Synonyms: MAP2K2, MEK2, MKK2, PRKMK2, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, MAPK/ERK kinase 2
NCBI Accession NP_109587
UniProt P36507
Pathways MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor
Application Notes WB: 1:1000,IF: 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) (AA 1-30), (N-Term) antibody (ABIN1882178) MEK2 (MAP2K2) Antibody (N-term) (ABIN1882178) western blot analysis in Hela,MCF-7,rat...
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) (AA 1-30), (N-Term) antibody (ABIN1882178) MEK2 (MAP2K2) Antibody (N-term) (ABIN1882178) western blot analysis in Hela,MCF-7,rat...
Product cited in: Burroughs, Oh, Barrett, DiAugustine et al.: "Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible ..." in: Molecular cancer research : MCR, Vol. 1, Issue 4, pp. 312-22, 2003 (PubMed).

Tran, Maurer, Nagamine: "Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2." in: Molecular and cellular biology, Vol. 23, Issue 20, pp. 7177-88, 2003 (PubMed).

Li, Junttila, Han, Kähäri, Westermarck: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." in: Cancer research, Vol. 63, Issue 13, pp. 3473-7, 2003 (PubMed).

Li, Inoki, Vacratsis, Guan: "The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13663-71, 2003 (PubMed).

Liu, Jana, Dasgupta, Koka, He, Wood, Pahan: "Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia." in: The Journal of biological chemistry, Vol. 277, Issue 42, pp. 39312-9, 2002 (PubMed).