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  • 产品名称：anti-EstrogenReceptor2(ERBeta)(ESR2)(AA211-240),(Center)antibody

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简单介绍：
anti-EstrogenReceptor2(ERBeta)(ESR2)(AA211-240),(Center)antibody
详情介绍：
Immunogen This ESR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ESR2.
Clone RB41114
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name ESR2 (ESR2 Antibody Abstract)
Background This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Synonyms: ESR2, ESTRB, NR3A2, Estrogen receptor beta, Nuclear receptor subfamily 3 group A member 2
NCBI Accession NP_001035365, NP_001258805, NP_001258806, NP_001201831, NP_001201832, NP_001428
UniProt Q92731
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Estrogen Receptor 2 (ER Beta) (ESR2) (AA 211-240), (Center) antibody (ABIN1881322) ESR2 Antibody (Center) (ABIN1881322) western blot analysis in T47D?MDA-MB453?Hela cel...
Product cited in: Fang, Lu, Wang, Wu, Li, Zhang, Pan, Wan: "Prognostic impact of ERβ and MMP7 expression on overall survival in colon cancer." in: Tumour biology, Vol. 31, Issue 6, pp. 651-8, 2010 (PubMed).

Hayes, Skaar, Rae, Henry, Nguyen, Stearns, Li, Philips, Desta, Flockhart: "Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results." in: Clinical pharmacology and therapeutics, Vol. 88, Issue 5, pp. 626-9, 2010 (PubMed).