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  • 产品名称：anti-VitaminDReceptorantibody(VDR)(AA274-299)

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简单介绍：
anti-VitaminDReceptorantibody(VDR)(AA274-299)
详情介绍：
Immunogen This VDR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-299 AA from the Central region of human VDR.
Clone RB24558
Isotype Ig
Specificity This VDR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-299 amino acids from the Central region of human VDR.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name VDR (VDR Antibody Abstract)
Background This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Synonyms: Vitamin D3 receptor,VDR,NR1I1
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Pathways Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Vitamin D Receptor (VDR) (AA 274-299), (Center) antibody (ABIN658714) VDR Antibody (Center) (ABIN658714) western blot analysis in Hela cell line lysates (3...
Background publications An, Tavera-Mendoza, Dimitrov, Wang, Calderon, Wang, White: "Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor." in: Molecular and cellular biology, Vol. 30, Issue 20, pp. 4890-900, 2010 (PubMed).