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  • 产品名称：anti-UBE3Cantibody(UbiquitinProteinLigaseE3C)(AA549-578)

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简单介绍：
anti-UBE3Cantibody(UbiquitinProteinLigaseE3C)(AA549-578)
详情介绍：
Immunogen This UBE3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-578 amino acids from the Central region of human UBE3C.
Clone RB44044
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name UBE3C (UBE3C Antibody Abstract)
Background E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'-or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.

Synonyms: UBE3C,KIAA0010, KIAA10, Ubiquitin-protein ligase E3C, Ubiquitin-protein ligase E3C, HectH2
NCBI Accession NP_055486
UniProt Q15386
Research Area Proteolysis / Ubiquitin
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.27 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin Protein Ligase E3C (UBE3C) (AA 549-578), (Center) antibody (ABIN1881969) UBE3C Antibody (Center) (ABIN1881969) western blot analysis in Hela cell line lysates...
Product cited in: Hillier, Fulton, Fulton, Graves, Pepin, Wagner-McPherson, Layman, Maas, Jaeger, Walker, Wylie, Sekhon, Becker, OLaughlin, Schaller, Fewell, Delehaunty, Miner, Nash, Cordes, Du, Sun, Edwards et al.: "The DNA sequence of human chromosome 7. ..." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Scherer, Cheung, MacDonald, Osborne, Nakabayashi, Herbrick, Carson, Parker-Katiraee, Skaug, Khaja, Zhang, Hudek, Li, Haddad, Duggan, Fernandez, Kanematsu, Gentles, Christopoulos, Choufani, Kwasnicka et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).

You, Pickart: "A HECT domain E3 enzyme assembles novel polyubiquitin chains." in: The Journal of biological chemistry, Vol. 276, Issue 23, pp. 19871-8, 2001 (PubMed).

Background publications Nomura, Miyajima, Sazuka, Tanaka, Kawarabayasi, Sato, Nagase, Seki, Ishikawa, Tabata et al.: "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature ..." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 1, Issue 1, pp. 27-35, 1995 (PubMed).