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  • 产品名称：anti-Nucleophosmin(NucleolarphosphoproteinB23,Numatrin)(NPM1)antibody

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简单介绍：
anti-Nucleophosmin(NucleolarphosphoproteinB23,Numatrin)(NPM1)antibody
详情介绍：
Immunogen Purified His-tagged NPM1 protein was used to produced this monoclonal antibody.
Clone 1042CT5-2-1
Isotype IgG1
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name NPM1 (NPM1 Antibody Abstract)
Background Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.

Synonyms: NPM1,NPM, Nucleophosmin, Nucleophosmin, Nucleolar phosphoprotein B23, Nucleophosmin, Nucleolar protein NO38, Nucleophosmin, Numatrin
NCBI Accession NP_002511, NP_954654, NP_001032827
UniProt P06748
Pathways Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) antibody (ABIN1882271) NPM1 Antibody (ABIN1882271) western blot analysis in Hela,Jurkat,MCF-7,mouse NIH/3T3 ...
Product cited in: Bolli, Galimberti, Martelli, Tabarrini, Roti, Mecucci, Martelli, Petrini, Falini: "Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia." in: The lancet oncology, Vol. 7, Issue 4, pp. 350-2, 2006 (PubMed).

Swaminathan, Kishore, Febitha, Kundu: "Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription." in: Molecular and cellular biology, Vol. 25, Issue 17, pp. 7534-45, 2005 (PubMed).

Tago, Chiocca, Sherr: "Sumoylation induced by the Arf tumor suppressor: a p53-independent function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 21, pp. 7689-94, 2005 (PubMed).