产品详情
所在位置: 首页> 产品目录> 一抗>
查看大图

  • 产品名称：anti-GFI1Bantibody(GrowthFactorIndependent1BTranscriptionRepressor)(AA302-330)

  • 产品型号：
  • 产品厂商：半导体
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
anti-GFI1Bantibody(GrowthFactorIndependent1BTranscriptionRepressor)(AA302-330)
详情介绍：
Immunogen This GFI1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human GFI1B.
Clone RB44051
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name GFI1B (GFI1B Antibody Abstract)
Background Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context, represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

Synonyms: Zinc finger protein Gfi-1b,Zinc finger protein Gfi-1b, Zinc finger protein Gfi-1b, Growth factor independent protein 1B, Zinc finger protein Gfi-1b, Potential regulator of CDKN1A translocated in CML
NCBI Accession NP_004179, NP_001128503
UniProt Q5VTD9
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 302-330), (C-Term) antibody (ABIN1881370) GFI1B Antibody (C-term) (ABIN1881370) western blot analysis in HL-60,K562,U266 cell l...
Product cited in: Huang, Kuo, Lai, Suzuki, Sugano, Chang: "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene." in: Nucleic acids research, Vol. 32, Issue 13, pp. 3935-46, 2004 (PubMed).

Rödel, Wagner, Zörnig, Niessing, Möröy: "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases." in: Genomics, Vol. 54, Issue 3, pp. 580-2, 1999 (PubMed).