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  • 产品名称：anti-YY1TranscriptionFactor(YY1)antibody

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简单介绍：
anti-YY1TranscriptionFactor(YY1)antibody
详情介绍：
Immunogen Purified His-tagged YY1 protein was used to produced this monoclonal antibody.
Clone 1183CT6-5-23-6
Isotype IgG2a
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name YY1 (YY1 Antibody Abstract)
Background Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of s or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair, proposed to target the INO80 complex to YY1-responsive elements.

Synonyms: YY1,INO80S, Transcriptional repressor protein YY1, Transcriptional repressor protein YY1, Delta transcription factor, Transcriptional repressor protein YY1, INO80 complex subunit S, Transcriptional repressor protein YY1, NF-E1, Transcriptional repressor protein YY1, Yin and yang 1
NCBI Accession NP_003394
UniProt P25490
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-YY1 Transcription Factor (YY1) antibody (ABIN1882292) YY1 Antibody (ABIN1882292) western blot analysis in Daudi and U251 cell line lysates ...
Product cited in: Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: "Initial characterization of the human central proteome." in: BMC systems biology, Vol. 5, pp. 17, 2011 (PubMed).

Chen, Cai, Jin, Florens, Swanson, Washburn, Conaway, Conaway: "Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11283-9, 2011 (PubMed).

Kim, Kim: "YY1's longer DNA-binding motifs." in: Genomics, Vol. 93, Issue 2, pp. 152-8, 2009 (PubMed).

Background publications Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).