产品详情
所在位置: 首页> 产品目录> 一抗>
查看大图

  • 产品名称：anti-NFKBIAantibody(NuclearFactorofkappaLightPolypeptideGeneEnhancerinB-CellsIn

  • 产品型号：
  • 产品厂商：半导体
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
anti-NFKBIAantibody(NuclearFactorofkappaLightPolypeptideGeneEnhancerinB-CellsInhibitor,alpha)
详情介绍：
Immunogen Purified His-tagged NFKBIA protein was used to produced this monoclonal antibody.
Clone 1121CT8-6-1
Isotype IgG1, kappa
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name NFKBIA (NFKBIA Antibody Abstract)
Background Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Synonyms: NFKBIA,IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, NF-kappa-B inhibitor alpha, Major histocompatibility complex enhancer-binding protein MAD3
NCBI Accession NP_065390
UniProt P25963
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN1882268) NFKBIA Antibody (ABIN1882268) western blot analysis in Hela,mouse NIH/3T3 cell line l...
Product cited in: Cockman, Lancaster, Stolze, Hewitson, McDonough, Coleman, Coles, Yu, Hay, Ley, Pugh, Oldham, Masson, Schofield, Ratcliffe: "Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 40, pp. 14767-72, 2006 (PubMed).

Jungnickel, Staratschek-Jox, Bräuninger, Spieker, Wolf, Diehl, Hansmann, Rajewsky, Küppers: "Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma." in: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 395-402, 2000 (PubMed).

Huxford, Huang, Malek, Ghosh: "The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation." in: Cell, Vol. 95, Issue 6, pp. 759-70, 1999 (PubMed).

Haskill, Beg, Tompkins, Morris, Yurochko, Sampson-Johannes, Mondal, Ralph, Baldwin: "Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity." in: Cell, Vol. 65, Issue 7, pp. 1281-9, 1991 (PubMed).