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  • 产品名称：anti-GRB10antibody(GrowthFactorReceptor-BoundProtein10)(AA1-30)

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简单介绍：
anti-GRB10antibody(GrowthFactorReceptor-BoundProtein10)(AA1-30)
详情介绍：
Immunogen This GRB10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GRB10.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name GRB10 (GRB10 Antibody Abstract)
Background Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Synonyms: GRB10,GRBIR, KIAA0207, Growth factor receptor-bound protein 10, Growth factor receptor-bound protein 10, GRB10 adapter protein, Growth factor receptor-bound protein 10, Insulin receptor-binding protein Grb-IR
NCBI Accession NP_001001550, NP_001001555, NP_001001549, NP_005302
UniProt Q13322
Research Area Signaling
Pathways Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.49 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 1-30), (N-Term) antibody (ABIN1881389) GRB10 Antibody (N-term) (ABIN1881389) western blot analysis in A549,MDA-MB453,U251 ce...
Product cited in: Nantel, Mohammad-Ali, Sherk, Posner, Thomas: "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10475-84, 1998 (PubMed).

Frantz, Giorgetti-Peraldi, Ottinger, Shoelson: "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2659-67, 1997 (PubMed).

Dong, Du, Porter, Kolakowski, Lee, Mandarino, Fan, Yee, Liu, Mandarino: "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma." in: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 29104-12, 1997 (PubMed).

ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22506-13, 1996 (PubMed).

Liu, Roth: "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 22, pp. 10287-91, 1995 (PubMed).