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  • 产品名称：anti-BRTC1/2(AA127-156),(N-Term)antibody

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简单介绍：
anti-BRTC1/2(AA127-156),(N-Term)antibody
详情介绍：
Immunogen This BRTC1/2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the N-terminal region of human BRTC1/2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Background Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

Synonyms: BTRC,BTRCP, FBW1A, FBXW1A, F-box/WD repeat-containing protein 1A, F-box/WD repeat-containing protein 1A, E3RSIkappaB, F-box/WD repeat-containing protein 1A, Epididymis tissue protein Li 2a, F-box/WD repeat-containing protein 1A, F-box and WD repeats protein beta-TrCP, F-box/WD repeat-containing protein 1A, pIkappaBalpha-E3 receptor subunit
NCBI Accession NP_378663, NP_003930
UniProt Q9Y297
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-BRTC1/2 (AA 127-156), (N-Term) antibody (ABIN1881122) BRTC1/2 Antibody (N-term) (ABIN1881122) western blot analysis in MDA-MB453,HepG2 cell...
Product cited in: Wan, Tang, Tytler, Lu, Jin, Vickers, Yang, Shi, Cao: "Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1." in: The Journal of biological chemistry, Vol. 279, Issue 15, pp. 14484-7, 2004 (PubMed).

Zhou, Deng, Xia, Xu, Li, Gunduz, Hung: "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition." in: Nature cell biology, Vol. 6, Issue 10, pp. 931-40, 2004 (PubMed).

Busino, Donzelli, Chiesa, Guardavaccaro, Ganoth, Dorrello, Hershko, Pagano, Draetta: "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage." in: Nature, Vol. 426, Issue 6962, pp. 87-91, 2003 (PubMed).

Yaron, Hatzubai, Davis, Lavon, Amit, Manning, Andersen, Mann, Mercurio, Ben-Neriah: "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase." in: Nature, Vol. 396, Issue 6711, pp. 590-4, 1999 (PubMed).

Margottin, Bour, Durand, Selig, Benichou, Richard, Thomas, Strebel, Benarous: "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif." in: Molecular cell, Vol. 1, Issue 4, pp. 565-74, 1998 (PubMed).