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  • 产品名称：anti-HIST2H2ACantibody(HistoneCluster2,H2ac)(AA18-46)

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简单介绍：
anti-HIST2H2ACantibody(HistoneCluster2,H2ac)(AA18-46)
详情介绍：
Immunogen This HIST2H2AC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the Central region of human HIST2H2AC.
Clone RB41799
Predicted Reactivity Cow (Bovine),Chicken,Fruit Fly (Drosophila melanogaster),Mouse (Murine),Monkey,Rat (Rattus),Xenopus laevis,Zebrafish (Danio rerio)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name HIST2H2AC
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family.

Synonyms: HIST2H2AC, H2AFQ, Histone H2A type 2-C, Histone H2A-GL101, Histone H2A/q
NCBI Accession NP_003508
UniProt Q16777
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Histone Cluster 2, H2ac (HIST2H2AC) (AA 18-46), (Center) antibody (ABIN1881417) HIST2H2AC Antibody (Center) (ABIN1881417) western blot analysis in 293 cell line lysa...
Product cited in: Ishibashi, Dryhurst, Rose, Shabanowitz, Hunt, Ausió: "Acetylation of vertebrate H2A.Z and its effect on the structure of the nucleosome." in: Biochemistry, Vol. 48, Issue 22, pp. 5007-17, 2009 (PubMed).

Karaczyn, Cheng, Buzard, Hartley, Esposito, Kasprzak: "Truncation of histone H2A's C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects." in: Annals of clinical and laboratory science, Vol. 39, Issue 3, pp. 251-62, 2009 (PubMed).

Zhao, Lang, Ito, Bonnet, Metzger, Sawatsubashi, Suzuki, Le Guezennec, Stunnenberg, Krasnov, Georgieva, Schüle, Takeyama, Kato, Tora, Devys: "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing." in: Molecular cell, Vol. 29, Issue 1, pp. 92-101, 2008 (PubMed).