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  • 产品名称：anti-MAP2K1antibody(Mitogen-ActivatedProteinKinaseKinase1)(AA1-30)

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简单介绍：
anti-MAP2K1antibody(Mitogen-ActivatedProteinKinaseKinase1)(AA1-30)
详情介绍：
Immunogen This MEK1 (MAP2K1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MEK1 (MAP2K1).
Clone RB0924
Predicted Reactivity Mouse (Murine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein G column, followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name MEK1 (MAP2K1) (MAP2K1 Antibody Abstract)
Background MEK1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Synonyms: MAP2K1, MEK1, PRKMK1, Dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAPK/ERK kinase 1
NCBI Accession NP_002746
UniProt Q02750
Pathways MAPK Signaling, RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor
Application Notes WB: 1:1000,IHC (p): 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (AA 1-30), (N-Term) antibody (ABIN1882177) MEK1 Antibody (M1) (ABIN1882177) western blot analysis in Jurkat,PC-12,rat C6 cell li...
Product cited in: Luo, Zhao, Shi, Feng, Chen, Li: "Induction of Apoptosis in Human Leukemic Cell Lines by Diallyl Disulfide via Modulation of EGFR/ERK/PKM2 Signaling Pathways." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 16, Issue 8, pp. 3509-15, 2015 (PubMed).

Zheng, Fiumara, Li, Georgakis, Snell, Younes, Vauthey, Carbone, Younes: "MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival." in: Blood, Vol. 102, Issue 3, pp. 1019-27, 2003 (PubMed).

Li, Junttila, Han, K?h?ri, Westermarck: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." in: Cancer research, Vol. 63, Issue 13, pp. 3473-7, 2003 (PubMed).

Zhu, Sun, Lee, Siedlak, Perry, Smith: "Distribution, levels, and activation of MEK1 in Alzheimer's disease." in: Journal of neurochemistry, Vol. 86, Issue 1, pp. 136-42, 2003 (PubMed).

Fringer, Grinnell: "Fibroblast quiescence in floating collagen matrices: decrease in serum activation of MEK and Raf but not Ras." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20612-7, 2003 (PubMed).

Witowsky, Johnson: "Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1403-6, 2003 (PubMed).