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  • 产品名称：anti-CyclinD1antibody(CCND1)(AA267-294)

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简单介绍：
anti-CyclinD1antibody(CCND1)(AA267-294)
详情介绍：
Immunogen This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-294 amino acids from the C-terminal region of human CCND1.
Clone RB42158
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CCND1 (CCND1 Antibody Abstract)
Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Synonyms: CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene
NCBI Accession NP_444284
UniProt P24385
Pathways PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.48 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Cyclin D1 (CCND1) (AA 267-294), (C-Term), (Thr288) antibody (ABIN1881175) CCND1 Antibody (T288) (ABIN1881175) western blot analysis in Hela cell line lysates (...
Product cited in: Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: "Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase." in: Cancer cell, Vol. 18, Issue 4, pp. 329-40, 2010 (PubMed).

Halilovic, She, Ye, Pagliarini, Sellers, Solit, Rosen: "PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling." in: Cancer research, Vol. 70, Issue 17, pp. 6804-14, 2010 (PubMed).

Zheng, Armes, Slavin, Zhu, Ni: "Preliminary comparison of tumor biologic factors in breast carcinomas from Australian and Chinese women." in: Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, Vol. 32, Issue 3, pp. 155-60, 2010 (PubMed).

Satiroglu-Tufan, Dodurga, Gok, Cetinkaya, Feitelson: "RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells." in: Genetics and molecular research : GMR, Vol. 9, Issue 3, pp. 1557-67, 2010 (PubMed).

Iwatani, Fujimoto, Ito: "Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction." in: Biochemical and biophysical research communications, Vol. 400, Issue 3, pp. 426-31, 2010 (PubMed).