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  • 产品名称：anti-CSH1antibody(ChorionicSomatomammotropinHormone1(PlacentalLactogen))(AA42-7

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简单介绍：
anti-CSH1antibody(ChorionicSomatomammotropinHormone1(PlacentalLactogen))(AA42-70)
详情介绍：
Immunogen This CSH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human CSH1.
Clone RB41664
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CSH1 (CSH1 Antibody Abstract)
Background The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq].

Synonyms: CSH1, Chorionic somatomammotropin hormone, Lactogen, Placental lactogen
NCBI Accession NP_066271, NP_001308
UniProt P01243
Pathways Response to Growth Hormone Stimulus
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.39 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1) (AA 42-70), (N-Term) antibody (ABIN1881233) CSH1 Antibody (N-term) (ABIN1881233) western blot analysis in NCI-H460 cell line lysa...
Product cited in: Voorhees, Brooks: "Obligate ordered binding of human lactogenic cytokines." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20022-30, 2010 (PubMed).

Männik, Vaas, Rull, Teesalu, Rebane, Laan: "Differential expression profile of growth hormone/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 5, pp. 2433-42, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Varvarigou, Liatsis, Vassilakos, Decavalas, Beratis: "Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol." in: Journal of perinatal medicine, Vol. 37, Issue 4, pp. 364-9, 2009 (PubMed).

Chen, Kibriya, Jasmine, Santella, Senie, Ahsan: "Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk." in: Cancer research, Vol. 68, Issue 23, pp. 9729-34, 2008 (PubMed).