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Alternative Name
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DAG1 (DAG1 Antibody Abstract)
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Background
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Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
Synonyms: Dystroglycan,DAG1,
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Molecular Weight
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97441 DA
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Gene ID
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1605
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NCBI Accession
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NP_001171111, NP_004384, NP_001171107
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UniProt
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Q14118
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Research Area
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Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
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Pathways
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Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
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