anti-Amyloidbeta(A4)Precursor-LikeProtein2(APLP2)(AA593-621),(C-Term)antibody 抗体网

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产品名称：anti-Amyloidbeta(A4)Precursor-LikeProtein2(APLP2)(AA593-621),(C-Term)antibody
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产品厂商：半导体
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简单介绍：

anti-Amyloidbeta(A4)Precursor-LikeProtein2(APLP2)(AA593-621),(C-Term)antibody

详情介绍：

Product details
Product details
Immunogen	This APLP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-621 AA from the C-terminal region of human APLP2.
Clone	RB34434
Isotype	Ig
Specificity	This APLP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-621 amino acids from the C-terminal region of human APLP2.
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.

Target details
Target details
Alternative Name	APLP2 (APLP2 Antibody Abstract)
Background	APLP2 may play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Synonyms: Amyloid-like protein 2,APLP2,APPL2
Research Area	Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Transcription Factors, Signaling
Pathways	EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Feeding Behaviour

Application Details
Application Details
Application Notes	WB = 1:1000, IHC (p) = 1:10-50
Restrictions	For Research Use only

Handling
Handling
Format	Liquid
Concentration	0.5 mg/mL
Buffer	PBS with 0.09 % (W/V) sodium azide
Preservative	Sodium azide
Precaution of Use	This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Images
Images
Supplier Images	APLP2 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/l... APLP2 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane)... APLP2 Antibody (C-term) (AP14673b)immunohistochemistry analysis in formalin fixed and... Images for product: anti-Amyloid beta (A4) Precursor-Like Protein 2 (APLP2) (AA 593-621), (C-Term) antibody APLP2 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the APLP2 antibody detected the APLP2 protein (arrow). APLP2 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the APLP2 antibody detected the APLP2 protein (arrow). APLP2 Antibody (C-term) (AP14673b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of APLP2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

References
References
Background publications	Tuli, Sharma, Capek, Naslavsky, Caplan, Solheim: "Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation." in: The Journal of biological chemistry, Vol. 284, Issue 49, pp. 34296-307, 2009 (PubMed). Tuli, Sharma, McIlhaney, Talmadge, Naslavsky, Caplan, Solheim: "Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 3, pp. 1978-87, 2008 (PubMed). Tuli, Sharma, Naslavsky, Caplan, Solheim: "Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules." in: Immunogenetics, Vol. 60, Issue 6, pp. 303-13, 2008 (PubMed).