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  • 产品名称：anti-PACS2antibody(phosphofurinAcidicClusterSortingProtein2)(AA642-671)

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简单介绍：
anti-PACS2antibody(phosphofurinAcidicClusterSortingProtein2)(AA642-671)
详情介绍：
Immunogen This PACS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 642-671 AA from the C-terminal region of human PACS2.
Clone RB32549
Isotype Ig
Specificity This PACS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 641-671 amino acids from the C-terminal region of human PACS2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PACS2 (PACS2 Antibody Abstract)
Background Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Synonyms: Phosphofurin acidic cluster sorting protein 2,PACS2,KIAA0602, PACS1L
Research Area Protein Modifications, Apoptosis/Necrosis, Cell Structure, Phospho-specific antibodies
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunohistochemistry (IHC) image for anti-phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) (AA 642-671), (C-Term) antibody (ABIN657066) PACS2 Antibody (C-term) (ABIN657066) immunohistochemistry analysis in formalin fixed ...
Background publications Myhill, Lynes, Nanji, Blagoveshchenskaya, Fei, Carmine Simmen, Cooper, Thomas, Simmen: "The subcellular distribution of calnexin is mediated by PACS-2." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2777-88, 2008 (PubMed).

Atkins, Thomas, Youker, Harriff, Pissani, You, Thomas: "HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice." in: The Journal of biological chemistry, Vol. 283, Issue 17, pp. 11772-84, 2008 (PubMed).