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  • 产品名称：anti-BAXantibody(BCL2-AssociatedXProtein)(AA28-56)

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简单介绍：
anti-BAXantibody(BCL2-AssociatedXProtein)(AA28-56)
详情介绍：
Immunogen This BAX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 AA from the N-terminal region of human BAX.
Clone RB32989
Isotype Ig
Specificity This BAX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human BAX.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BAX (BAX Antibody Abstract)
Background The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Synonyms: Apoptosis regulator BAX,BAX,BCL2L4
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Cell Structure, Cancer
Pathways p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded protein response
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-BCL2-Associated X Protein (BAX) (AA 28-56), (N-Term) antibody (ABIN657135) BAX Antibody (N-term) (ABIN657135) western blot analysis in K562 cell line lysates (3...
Background publications Ding, Zhang, Roberts, Falcone, Miao, Shao, Zhang, Andrews, Lin: "Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif." in: The Journal of biological chemistry, Vol. 285, Issue 37, pp. 28749-63, 2010 (PubMed).