anti-Beclin1antibody(Beclin1,AutophagyRelated)(pSer64) 抗体网

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产品名称：anti-Beclin1antibody(Beclin1,AutophagyRelated)(pSer64)
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anti-Beclin1antibody(Beclin1,AutophagyRelated)(pSer64)

详情介绍：

Product Details anti-Beclin 1 Antibody
Product Details anti-Beclin 1 Antibody
Immunogen	This beclin 1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S64 of human beclin 1.
Clone	RB41700
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Target Details Beclin 1
Target Details Beclin 1
Alternative Name	beclin 1 (BECN1 Antibody Abstract)
Background	Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration . Synonyms: BECN1, GT197, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197
NCBI Accession	NP_003757
UniProt	Q14457
Pathways	Autophagy

Application Details
Application Details
Application Notes	DB: 1:500
Restrictions	For Research Use only

Handling
Handling
Format	Liquid
Concentration	0.27 mg/mL
Buffer	Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative	Sodium azide
Precaution of Use	WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Images
Images
Supplier Images	Dot blot analysis of beclin 1 Antibody (Phospho S64) Phospho-specific Pab (ABIN188111... Dot blot analysis of beclin 1 Antibody (Phospho S64) Phospho-specific Pab (ABIN1881111) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6 µg per mL. Dot blot analysis of beclin 1 Antibody (Phospho S64) Phospho-specific Pab (ABIN1881111) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6 µg per mL.

References for anti-Beclin 1 antibody (ABIN1881111)
References for anti-Beclin 1 antibody (ABIN1881111)
Background publications	Koukourakis, Giatromanolaki, Sivridis, Pitiakoudis, Gatter, Harris: "Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia." in: British journal of cancer, Vol. 103, Issue 8, pp. 1209-14, 2010 (PubMed). Jaeger, Wyss-Coray: "Beclin 1 complex in autophagy and Alzheimer disease." in: Archives of neurology, Vol. 67, Issue 10, pp. 1181-4, 2010 (PubMed). Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: "Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7." in: Human genetics, Vol. 128, Issue 4, pp. 453-9, 2010 (PubMed). Zhong, Wang, Li, Yan, Backer, Chait, Heintz, Yue: "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex." in: Nature cell biology, Vol. 11, Issue 4, pp. 468-76, 2009 (PubMed). Oberstein, Jeffrey, Shi: "Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein." in: The Journal of biological chemistry, Vol. 282, Issue 17, pp. 13123-32, 2007 (PubMed). Furuya, Yu, Byfield, Pattingre, Levine: "The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function." in: Autophagy, Vol. 1, Issue 1, pp. 46-52, 2006 (PubMed).