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  • 产品名称：anti-PSMD12antibody(Proteasome(Prosome,Macropain)26SSubunit,Non-ATPase,12)(AA27

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简单介绍：
anti-PSMD12antibody(Proteasome(Prosome,Macropain)26SSubunit,Non-ATPase,12)(AA276-304)
详情介绍：
Immunogen This PSMD12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-304 amino acids from the Central region of human PSMD12.
Clone RB42427
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name PSMD12 (PSMD12 Antibody Abstract)
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.

Synonyms: PSMD12, 26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit RPN5, 26S proteasome regulatory subunit p55
NCBI Accession NP_777360, NP_002807
UniProt O00232
Pathways Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 12 (PSMD12) (AA 276-304), (Center) antibody (ABIN1881697) PSMD12 Antibody (Center) (ABIN1881697) western blot analysis in WiDr cell line lysate...
Product cited in: Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).

Gandhi, Zhong, Mathivanan, Karthick, Chandrika, Mohan, Sharma, Pinkert, Nagaraju, Periaswamy, Mishra, Nandakumar, Shen, Deshpande, Nayak, Sarker, Boeke, Parmigiani, Schultz, Bader, Pandey: "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets." in: Nature genetics, Vol. 38, Issue 3, pp. 285-93, 2006 (PubMed).

Listovsky, Oren, Yudkovsky, Mahbubani, Weiss, Lebendiker, Brandeis: "Mammalian Cdh1/Fzr mediates its own degradation." in: The EMBO journal, Vol. 23, Issue 7, pp. 1619-26, 2004 (PubMed).

Bouwmeester, Bauch, Ruffner, Angrand, Bergamini, Croughton, Cruciat, Eberhard, Gagneur, Ghidelli, Hopf, Huhse, Mangano, Michon, Schirle, Schlegl, Schwab, Stein, Bauer, Casari, Drewes, Gavin, Jackson et al.: "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. ..." in: Nature cell biology, Vol. 6, Issue 2, pp. 97-105, 2004 (PubMed).

Background publications Conticello, Harris, Neuberger: "The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G." in: Current biology : CB, Vol. 13, Issue 22, pp. 2009-13, 2003 (PubMed).