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  • 产品名称：anti-RECQL4antibody(RecQProtein-Like4)(AA1134-1162)

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简单介绍：
anti-RECQL4antibody(RecQProtein-Like4)(AA1134-1162)
详情介绍：
Immunogen This RECQL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1134-1162 amino acids from the C-terminal region of human RECQL4.
Clone RB40513
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name RECQL4 (RECQL4 Antibody Abstract)
Background The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq].

Synonyms: RECQL4, RECQ4, ATP-dependent DNA helicase Q4, DNA helicase, RecQ-like type 4, RTS, RecQ protein-like 4
NCBI Accession NP_004251
UniProt O94761
Pathways Chromatin Binding
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.37 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-RecQ Protein-Like 4 (RECQL4) (AA 1134-1162), (C-Term) antibody (ABIN1881738) RECQL4 Antibody (C-term) (ABIN1881738) western blot analysis in mouse testis tissue l...
Product cited in: Rossi, Ghosh, Kulikowicz, Croteau, Bohr: "Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding." in: DNA repair, Vol. 9, Issue 7, pp. 796-804, 2010 (PubMed).

Singh, Karmakar, Aamann, Schurman, May, Croteau, Burks, Plon, Bohr: "The involvement of human RECQL4 in DNA double-strand break repair." in: Aging cell, Vol. 9, Issue 3, pp. 358-71, 2010 (PubMed).

Thangavel, Mendoza-Maldonado, Tissino, Sidorova, Yin, Wang, Monnat, Falaschi, Vindigni: "Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1382-96, 2010 (PubMed).

Xu, Rochette, Feyissa, Su, Liu: "MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication." in: The EMBO journal, Vol. 28, Issue 19, pp. 3005-14, 2009 (PubMed).

Im, Ki, Farina, Jung, Hurwitz, Lee: "Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 37, pp. 15628-32, 2009 (PubMed).