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  • 产品名称：anti-LATS2antibody(LATS,LargeTumorSuppressor,Homolog2(Drosophila))(AA1000-1027)

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简单介绍：
anti-LATS2antibody(LATS,LargeTumorSuppressor,Homolog2(Drosophila))(AA1000-1027)
详情介绍：
Immunogen This Mouse Lats2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1027 amino acids from the C-terminal region of mouse Lats2.
Clone RB40566
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Lats2 (LATS2 Antibody Abstract)
Background Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).

Synonyms: Lats2, Serine/threonine-protein kinase LATS2, Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm
NCBI Accession NP_056586
UniProt Q7TSJ6
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027), (C-Term) antibody (ABIN1881491) Mouse Lats2 Antibody (C-term) (ABIN1881491) western blot analysis in mouse testis tis...
Product cited in: Oh, Lee, Kim, Kim, Oh, Hwang, Kong, Kwon, Lim: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, 2009 (PubMed).

Quina, Wang, Ng, Turner: "Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 45, pp. 14309-22, 2009 (PubMed).

Nishioka, Inoue, Adachi, Kiyonari, Ota, Ralston, Yabuta, Hirahara, Stephenson, Ogonuki, Makita, Kurihara, Morin-Kensicki, Nojima, Rossant, Nakao, Niwa, Sasaki: "The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass." in: Developmental cell, Vol. 16, Issue 3, pp. 398-410, 2009 (PubMed).

Matsui, Nakano, Shao, Gao, Luo, Hong, Zhai, Holle, Yu, Yabuta, Tao, Wagner, Nojima, Sadoshima: "Lats2 is a negative regulator of myocyte size in the heart." in: Circulation research, Vol. 103, Issue 11, pp. 1309-18, 2008 (PubMed).