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  • 产品名称：anti-MMP14antibody(MatrixMetallopeptidase14(Membrane-inserted))(AA470-499)

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简单介绍：
anti-MMP14antibody(MatrixMetallopeptidase14(Membrane-inserted))(AA470-499)
详情介绍：
Immunogen This MMP14 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 470-499 AA from the C-terminal region of human MMP14.
Clone 133CT15-10-5-1
Isotype IgM
Specificity This MMP14 monoclonal antibody is generated from mouse immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MMP14.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name MMP14 (MMP14 Antibody Abstract)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Synonyms: MMP-X1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Matrix metalloproteinase-14, MMP-14,MMP14
Molecular Weight 65884 DA
Gene ID 4323
NCBI Accession NP_004986
UniProt P50281
Research Area Cell Signaling, Cell Structure, Protein Modifications, Metabolism
Pathways Autophagy
Application Notes WB = 1:100-500, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (AA 470-499), (C-Term) antibody (ABIN658994) MMP14 Monoclonal Antibody (C-term) western blot analysis in A2058 cell line lysates ...
Immunofluorescence (IF) image for anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (AA 470-499), (C-Term) antibody (ABIN658994) Confocal immunofluorescent analysis of MMP14 Antibody (C-term) with HepG2 cell follo...