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  • 产品名称：anti-SENP1antibody(SUMO1/sentrinSpecificPeptidase1)(AA262-289)

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简单介绍：
anti-SENP1antibody(SUMO1/sentrinSpecificPeptidase1)(AA262-289)
详情介绍：
Immunogen This Mouse Senp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-289 amino acids from the Central region of mouse Senp1.
Clone RB40856
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Senp1 (SENP1 Antibody Abstract)
Background Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.

Synonyms: Senp1, Supr2, Sentrin-specific protease 1, SUMO-1 protease 2, Sentrin/SUMO-specific protease SENP1
NCBI Accession NP_659100
UniProt P59110
Pathways Positive Regulation of Endopeptidase Activity
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.27 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-SUMO1/sentrin Specific Peptidase 1 (SENP1) (AA 262-289), (Center) antibody (ABIN1881788) Mouse Senp1 Antibody (Center) (ABIN1881788) western blot analysis in mouse Neuro-2a c...
Product cited in: Bawa-Khalfe, Cheng, Lin, Ittmann, Yeh: "SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25859-66, 2010 (PubMed).

Yu, Ji, Zhang, Renda, He, Lin, Cheng, Chen, Krause, Min: "SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis." in: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1183-95, 2010 (PubMed).

Sharma, Murillas, Zhang, Kuehn: "N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies." in: Journal of cell science, Vol. 123, Issue Pt 8, pp. 1227-34, 2010 (PubMed).

Li, Luo, Yu, Lin, Luo, Zhang, He, Kim, Kim, Tang, Min: "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis." in: Cell death and differentiation, Vol. 15, Issue 4, pp. 739-50, 2008 (PubMed).

Cheng, Kang, Zhang, Yeh: "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia." in: Cell, Vol. 131, Issue 3, pp. 584-95, 2007 (PubMed).