产品详情
所在位置: 首页> 产品目录> 一抗>
查看大图

  • 产品名称：anti-RetinoicAcidEarlyTranscript1E(RAET1E)(AA150-179),(Center)antibody

  • 产品型号：
  • 产品厂商：半导体
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
anti-RetinoicAcidEarlyTranscript1E(RAET1E)(AA150-179),(Center)antibody
详情介绍：
Immunogen This RAET1E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the Central region of human RAET1E.
Clone RB40835
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name RAET1E (RAET1E Antibody Abstract)
Background Members of the RAET1 family, such as RAET1E, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and RAET1G (MIM 609244) differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1, MIM 605697) in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a ligand for NKG2D (KLRK1, MIM 611817), which is expressed on the surface of several types of immune cells and is involved in innate and adaptive immune responses .

Synonyms: RAET1E, LETAL, N2DL4, ULBP4, NKG2D ligand 4, Lymphocyte effector toxicity activation ligand, RAE-1-like transcript 4, Retinoic acid early transcript 1E
NCBI Accession NP_001230256, NP_001230257, NP_631904, NP_001230254
UniProt Q8TD07
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Retinoic Acid Early Transcript 1E (RAET1E) (AA 150-179), (Center) antibody (ABIN1881724) RAET1E Antibody (Center) (ABIN1881724) western blot analysis in A2058 cell line lysat...
Background publications McGilvray, Eagle, Rolland, Jafferji, Trowsdale, Durrant: "ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients." in: International journal of cancer. Journal international du cancer, Vol. 127, Issue 6, pp. 1412-20, 2010 (PubMed).

Antoun, Jobson, Cook, OCallaghan, Moss, Briggs: "Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations." in: Human immunology, Vol. 71, Issue 6, pp. 610-20, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Romphruk, Romphruk, Naruse, Raroengjai, Puapairoj, Inoko, Leelayuwat: "Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais." in: Immunogenetics, Vol. 61, Issue 9, pp. 611-7, 2009 (PubMed).

Kong, Cao, Xi, Ma, Cui, He: "The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D." in: Blood, Vol. 114, Issue 2, pp. 310-7, 2009 (PubMed).

Cao, Xi, Hao, Li, Kong, Cui, Ma, Ba, He: "RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity." in: The Journal of biological chemistry, Vol. 282, Issue 26, pp. 18922-8, 2007 (PubMed).

Radosavljevic, Cuillerier, Wilson, Clément, Wicker, Gilfillan, Beck, Trowsdale, Bahram: "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3." in: Genomics, Vol. 79, Issue 1, pp. 114-23, 2002 (PubMed).