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  • 产品名称：anti-PotassiumChannelSubfamilyKMember6(KCNK6)(AA263-292),(C-Term)antibody

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  • 产品厂商：半导体
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简单介绍：
anti-PotassiumChannelSubfamilyKMember6(KCNK6)(AA263-292),(C-Term)antibody
详情介绍：
Immunogen This KCNK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human KCNK6.
Clone RB32356
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name KCNK6 (KCNK6 Antibody Abstract)
Background This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq].

Synonyms: KCNK6, TOSS, TWIK2, Potassium channel subfamily K member 6, Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence
NCBI Accession NP_004814
UniProt Q9Y257
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Potassium Channel Subfamily K Member 6 (KCNK6) (AA 263-292), (C-Term) antibody (ABIN1881475) KCNK6 Antibody (C-term) (ABIN1881475) western blot analysis in MDA-MB468 cell line ly...
Product cited in: Sebastiani, Solovieff, Hartley, Milton, Riva, Dworkis, Melista, Klings, Garrett, Telen, Ashley-Koch, Baldwin, Steinberg: "Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study." in: American journal of hematology, Vol. 85, Issue 1, pp. 29-35, 2009 (PubMed).

Goldstein, Bayliss, Kim, Lesage, Plant, Rajan: "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 527-40, 2005 (PubMed).

Mhatre, Li, Chen, Yost, Smith, Kindler, Lalwani: "Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4." in: Journal of neuroscience research, Vol. 75, Issue 1, pp. 25-31, 2003 (PubMed).

Goldstein, Bockenhauer, OKelly, Zilberberg: "Potassium leak channels and the KCNK family of two-P-domain subunits." in: Nature reviews. Neuroscience, Vol. 2, Issue 3, pp. 175-84, 2001 (PubMed).

Background publications Gierten, Ficker, Bloehs, Schlömer, Kathöfer, Scholz, Zitron, Kiesecker, Bauer, Becker, Katus, Karle, Thomas: "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein." in: British journal of pharmacology, Vol. 154, Issue 8, pp. 1680-90, 2008 (PubMed).