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  • 产品名称：anti-DISC1antibody(DisruptedinSchizophrenia1)(AA701-728)

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简单介绍：
anti-DISC1antibody(DisruptedinSchizophrenia1)(AA701-728)
详情介绍：
Immunogen This DISC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-728 AA from the C-terminal region of human DISC1.
Clone RB31996
Isotype Ig
Specificity This DISC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 700-728 amino acids from the C-terminal region of human DISC1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DISC1 (DISC1 Antibody Abstract)
Background This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1,11)(q42.1,q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Synonyms: Disrupted in schizophrenia 1 protein,DISC1,KIAA0457
Research Area Cell Signaling, Signaling, Chromatin, Neurology, Cell Structure
Pathways Regulation of Cell Size
Application Notes WB = 1:1000, FACS = 1:10-50, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.39 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Disrupted in Schizophrenia 1 (DISC1) (AA 701-728), (C-Term) antibody (ABIN658716) DISC1 Antibody (C-term) (ABIN658716) western blot analysis in Ramos cell line lysates...
Background publications Raznahan, Lee, Long, Greenstein, Clasen, Addington, Rapoport, Giedd: "Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents." in: Molecular psychiatry, Vol. 16, Issue 9, pp. 917-26, 2011 (PubMed).

Park, Jeong, Lee, Mun, Kim, Lee, Nguyen, Han, Suh, Park: "Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 41, pp. 17785-90, 2010 (PubMed).

Rua?o, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).