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  • 产品名称：anti-WWOXantibody(WWDomainContainingOxidoreductase)(AA369-396)

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简单介绍：
anti-WWOXantibody(WWDomainContainingOxidoreductase)(AA369-396)
详情介绍：
Immunogen This WWOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-396 AA from the C-terminal region of human WWOX.
Clone RB19946
Isotype Ig
Specificity This WWOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-396 amino acids from the C-terminal region of human WWOX.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WWOX (WWOX Antibody Abstract)
Background WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
Synonyms: WW domain-containing oxidoreductase,WWOX,FOR, WOX1
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-WW Domain Containing Oxidoreductase (WWOX) (AA 369-396), (C-Term) antibody (ABIN658713) WWOX Antibody (C-term) (ABIN658713) western blot analysis in mouse testis tissue lysa...
Background publications Kurek, Del Mare, Salah, Abdeen, Sadiq, Lee, Gaudio, Zanesi, Jones, DeYoung, Amir, Gebhardt, Warman, Stein, Stein, Lian, Aqeilan: "Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression." in: Cancer research, Vol. 70, Issue 13, pp. 5577-86, 2010 (PubMed).

Lin, Wang, Huang, Wang: "[The relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma]." in: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, Vol. 18, Issue 5, pp. 357-60, 2010 (PubMed).