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  • 产品名称：anti-Kallikrein15antibody(Kallikrein-RelatedPeptidase15)(AA78-106)

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简单介绍：
anti-Kallikrein15antibody(Kallikrein-RelatedPeptidase15)(AA78-106)
详情介绍：
Immunogen This KLK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 AA from the Central region of human KLK15.
Clone RB34526
Isotype Ig
Specificity This KLK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-106 amino acids from the Central region of human KLK15.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KLK15 (KLK15 Antibody Abstract)
Background Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: Kallikrein-15,KLK15,
Research Area Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Pathways Complement System
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Kallikrein-Related Peptidase 15 (KLK15) (AA 78-106), (Center) antibody (ABIN658745) KLK15 Antibody (Center) (ABIN658745) western blot analysis in CEM cell line lysates (...
Background publications Rabien, Fritzsche, Jung, T?lle, Diamandis, Miller, Jung, Kristiansen, Stephan: "KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy." in: International journal of cancer. Journal international du cancer, Vol. 127, Issue 10, pp. 2386-94, 2010 (PubMed).

Gallagher, Vijai, Cronin, Bhatia, Vickers, Gaudet, Fine, Reuter, Scher, Halldén, Dutra-Clarke, Klein, Scardino, Eastham, Lilja, Kirchhoff, Offit: "Susceptibility loci associated with prostate cancer progression and mortality." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 10, pp. 2819-32, 2010 (PubMed).