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  • 产品名称：anti-WIPI2antibody(WDRepeatDomain,PhosphoinositideInteracting2)(AA4-32)

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简单介绍：
anti-WIPI2antibody(WDRepeatDomain,PhosphoinositideInteracting2)(AA4-32)
详情介绍：
Immunogen This WIPI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 AA from the N-terminal region of human WIPI2.
Clone RB33312
Isotype Ig
Specificity This WIPI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human WIPI2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WIPI2 (WIPI2 Antibody Abstract)
Background WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).
Synonyms: WD repeat domain phosphoinositide-interacting protein 2,WIPI2,
Research Area Protein Modifications, Cell Structure, Phospho-specific antibodies
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunohistochemistry (IHC) image for anti-WD Repeat Domain, Phosphoinositide Interacting 2 (WIPI2) (AA 4-32), (N-Term) antibody (ABIN657237) WIPI2 Antibody (N-term) (ABIN657237) immunohistochemistry analysis in formalin fixed ...
Product cited in: Burbulla, Fitzgerald, Stegen, Westermeier, Thost, Kato, Mokranjac, Sauerwald, Martins, Woitalla, Rapaport, Riess, Proikas-Cezanne, Rasse, Krüger: "Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1." in: Cell death & disease, Vol. 5, pp. e1180, 2014 (PubMed).

Nemazanyy, Blaauw, Paolini, Caillaud, Protasi, Mueller, Proikas-Cezanne, Russell, Guan, Nishino, Sandri, Pende, Panasyuk: "Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease." in: EMBO molecular medicine, Vol. 5, Issue 6, pp. 870-90, 2013 (PubMed).

Background publications Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Proikas-Cezanne, Waddell, Gaugel, Frickey, Lupas, Nordheim: "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." in: Oncogene, Vol. 23, Issue 58, pp. 9314-25, 2004 (PubMed).