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  • 产品名称：anti-NLRC4antibody(NLRFamily,CARDDomainContaining4)(AA116-145)

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简单介绍：
anti-NLRC4antibody(NLRFamily,CARDDomainContaining4)(AA116-145)
详情介绍：
Immunogen This NLRC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 AA from the N-terminal region of human NLRC4.
Clone RB33296
Isotype Ig
Specificity This NLRC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-145 amino acids from the N-terminal region of human NLRC4.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NLRC4 (NLRC4 Antibody Abstract)
Background In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
Synonyms: NLR family CARD domain-containing protein 4,NLRC4,CARD12, CLAN, CLAN1, IPAF
Research Area Apoptosis/Necrosis, Signaling, Chromatin, Cell Structure
Pathways Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 116-145), (N-Term) antibody (ABIN657230) NLRC4 Antibody (N-term) (ABIN657230) western blot analysis in MDA-MB231 cell line lys...
Background publications Vinzing, Eitel, Lippmann, Hocke, Zahlten, Slevogt, Nguessan, Günther, Schmeck, Hippenstiel, Flieger, Suttorp, Opitz: "NAIP and Ipaf control Legionella pneumophila replication in human cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 10, pp. 6808-15, 2008 (PubMed).