anti-SGPP1antibody(Sphingosine-1-PhosphatePhosphatase1)(AA13-42) 抗体网

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产品名称：anti-SGPP1antibody(Sphingosine-1-PhosphatePhosphatase1)(AA13-42)
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简单介绍：

anti-SGPP1antibody(Sphingosine-1-PhosphatePhosphatase1)(AA13-42)

详情介绍：

Product Details anti-SGPP1 Antibody
Product Details anti-SGPP1 Antibody
Immunogen	This SGPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 AA from the N-terminal region of human SGPP1.
Clone	RB33048
Isotype	Ig
Specificity	This SGPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-42 amino acids from the N-terminal region of human SGPP1.
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.

Target Details SGPP1
Target Details SGPP1
Alternative Name	SGPP1 (SGPP1 Antibody Abstract)
Background	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351], Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM]. Synonyms: Sphingosine-1-phosphate phosphatase 1,SGPP1,
Research Area	Phospho-specific antibodies, Protein Modifications, Cell Structure, Metabolism

Application Details
Application Details
Application Notes	WB = 1:1000, IHC (p) = 1:10-50
Restrictions	For Research Use only

Handling
Handling
Format	Liquid
Concentration	0.5 mg/mL
Buffer	PBS with 0.09 % (W/V) sodium azide
Preservative	Sodium azide
Precaution of Use	This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Images
Images
Supplier Images	SGPP1 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/la... SGPP1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin ... Images for product: anti-Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) (AA 13-42), (N-Term) antibody SGPP1 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SGPP1 antibody detected the SGPP1 protein (arrow). SGPP1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SGPP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

References for anti-SGPP1 antibody (ABIN657152)
References for anti-SGPP1 antibody (ABIN657152)
Background publications	Hicks, Pramstaller, Johansson, Vitart, Rudan, Ugocsai, Aulchenko, Franklin, Liebisch, Erdmann, Jonasson, Zorkoltseva, Pattaro, Hayward, Isaacs, Hengstenberg, Campbell, Gnewuch, Janssens, Kirichenko, K?nig, Marroni, Polasek, Demirkan, Kolcic, Schwienbacher: "Genetic determinants of circulating sphingolipid concentrations in European populations." in: PLoS genetics, Vol. 5, Issue 10, pp. e1000672, 2009 (PubMed). Le Stunff, Giussani, Maceyka, Lépine, Milstien, Spiegel: "Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2." in: The Journal of biological chemistry, Vol. 282, Issue 47, pp. 34372-80, 2007 (PubMed). Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed). Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).