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  • 产品名称：anti-FGD2antibody(FYVE,RhoGEFandPHDomainContaining2)(AA508-537)

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简单介绍：
anti-FGD2antibody(FYVE,RhoGEFandPHDomainContaining2)(AA508-537)
详情介绍：
Immunogen This FGD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-537 AA from the C-terminal region of human FGD2.
Clone RB32867
Isotype Ig
Specificity This FGD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-537 amino acids from the C-terminal region of human FGD2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FGD2 (FGD2 Antibody Abstract)
Background FGD2 activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).
Synonyms: FYVE, RhoGEF and PH domain-containing protein 2,FGD2,ZFYVE4
Research Area Cell Structure, Signaling, Chromatin
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunohistochemistry (IHC) image for anti-FYVE, RhoGEF and PH Domain Containing 2 (FGD2) (AA 508-537), (C-Term) antibody (ABIN657115) FGD2 Antibody (C-term) (ABIN657115) immunohistochemistry analysis in formalin fixed a...
Background publications Huber, M?rtensson, Bokoch, Nemazee, Gavin: "FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 34002-12, 2008 (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).