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  • 产品名称：anti-Unc-13HomologB(C.Elegans)(UNC13B)(AA263-292),(N-Term)antibody

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简单介绍：
anti-Unc-13HomologB(C.Elegans)(UNC13B)(AA263-292),(N-Term)antibody
详情介绍：
Immunogen This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 AA from the N-terminal region of human UNC13B.
Clone RB32155
Isotype Ig
Specificity This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-292 amino acids from the N-terminal region of human UNC13B.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name UNC13B (UNC13B Antibody Abstract)
Background This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq].
Synonyms: Protein unc-13 homolog B,UNC13B,UNC13
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure, Neurology
Pathways Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Unc-13 Homolog B (C. Elegans) (UNC13B) (AA 263-292), (N-Term) antibody (ABIN657040) UNC13B Antibody (N-term) (ABIN657040) western blot analysis in mouse stomach tissue l...
Background publications Trégouet, Groop, McGinn, Forsblom, Hadjadj, Marre, Parving, Tarnow, Telgmann, Godefroy, Nicaud, Rousseau, Parkkonen, Hoverfält, Gut, Heath, Matsuda, Cox, Kazeem, Farrall, Gauguier, Brand-Herrmann, Cambien, Lathrop, Vionnet,: "G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes." in: Diabetes, Vol. 57, Issue 10, pp. 2843-50, 2008 (PubMed).