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  • 产品名称：anti-DUSP6antibody(DualSpecificityPhosphatase6)(AA1-381)

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简单介绍：
anti-DUSP6antibody(DualSpecificityPhosphatase6)(AA1-381)
详情介绍：
Immunogen This Rat MKP3 antibody is generated from rabbits immunized with a 6xHIS-tagged recombinant protein encoding aa 1~381 of rat MKP3.
Clone RB7281
Purification This antibody is purified through a protein A column, followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name MKP3 (DUSP6 Antibody Abstract)
Background Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of MAP kinases by dephosphorylating critical tyrosine and threonine residues. MKP-3 is 36% identical to MKP-1 and it blocks both the phosphorylation and enzymatic activation of ERK2 by mitogens. MKP-3 mRNA is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis

Synonyms: Dusp6, Mkp3, Dual specificity protein phosphatase 6, Mitogen-activated protein kinase phosphatase 3
NCBI Accession NP_446335
UniProt Q64346
Pathways Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
Application Notes WB: 1:1000,FACS: 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Flow Cytometry (FACS) image for anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 1-381) antibody (ABIN1882185) Rat MKP3 Antibody (ABIN1882185) flow cytometric analysis of 293 cells (right histogra...
Western Blotting (WB) image for anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 1-381) antibody (ABIN1882185) Rat MKP3 Antibody (ABIN1882185) flow cytometric analysis of 293 cells (right histogra...
Product cited in: Olson, Protheroe, Segar, Scholz: "Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 290, Issue 4, pp. H1587-95, 2006 (PubMed).

Muda, Boschert, Dickinson, Martinou, Martinou, Camps, Schlegel, Arkinstall: "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase." in: The Journal of biological chemistry, Vol. 271, Issue 8, pp. 4319-26, 1996 (PubMed).

Mourey, Vega, Campbell, Wenderoth, Hauschka, Krebs, Dixon: "A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation." in: The Journal of biological chemistry, Vol. 271, Issue 7, pp. 3795-802, 1996 (PubMed).