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  • 产品名称：anti-tyrosyl-tRNASynthetase2,Mitochondrial(YARS2)(AA399-427),(C-Term)antibody

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简单介绍：
anti-tyrosyl-tRNASynthetase2,Mitochondrial(YARS2)(AA399-427),(C-Term)antibody
详情介绍：
Immunogen This YARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the C-terminal region of human YARS2.
Clone RB14936
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name YARS2 (YARS2 Antibody Abstract)
Background YARS2 catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Synonyms: YARS2, Tyrosine--tRNA ligase, mitochondrial, Tyrosyl-tRNA synthetase
NCBI Accession NP_001035526
UniProt Q9Y2Z4
Application Notes WB: 1:1000,IHC (p): 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Immunohistochemistry (IHC) image for anti-tyrosyl-tRNA Synthetase 2, Mitochondrial (YARS2) (AA 399-427), (C-Term) antibody (ABIN1882153) Western blot analysis of anti-YARS2 Antibody (C-term) (ABIN1882153) in CEM cell line ...
Western Blotting (WB) image for anti-tyrosyl-tRNA Synthetase 2, Mitochondrial (YARS2) (AA 399-427), (C-Term) antibody (ABIN1882153) Western blot analysis of anti-YARS2 Antibody (C-term) (ABIN1882153) in CEM cell line ...
Product cited in: Riley, Menezes, Rudinger-Thirion, Duff, de Lonlay, Rotig, Tchan, Davis, Cooper, Christodoulou: "Phenotypic variability and identification of novel YARS2 mutations in YARS2 mitochondrial myopathy, lactic acidosis and sideroblastic anaemia." in: Orphanet journal of rare diseases, Vol. 8, pp. 193, 2013 (PubMed).

Riley, Cooper, Hickey, Rudinger-Thirion, McKenzie, Compton, Lim, Thorburn, Ryan, Giegé, Bahlo, Christodoulou: "Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome." in: American journal of human genetics, Vol. 87, Issue 1, pp. 52-9, 2010 (PubMed).

Bonnefond, Frugier, Touzé, Lorber, Florentz, Giegé, Sauter, Rudinger-Thirion: "Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features." in: Structure (London, England : 1993), Vol. 15, Issue 11, pp. 1505-16, 2007 (PubMed).