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  • 产品名称：anti-ISCUantibody(Iron-SulfurClusterScaffoldHomolog(E.Coli))(AA138-167)

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简单介绍：
anti-ISCUantibody(Iron-SulfurClusterScaffoldHomolog(E.Coli))(AA138-167)
详情介绍：
Immunogen This ISCU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the C-terminal region of human ISCU.
Clone RB35591
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name ISCU (ISCU Antibody Abstract)
Background Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Synonyms: ISCU, NIFUN, Iron-sulfur cluster assembly enzyme ISCU, mitochondrial, NifU-like N-terminal domain-containing protein, NifU-like protein
NCBI Accession NP_998760, NP_055116
UniProt Q9H1K1
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.29 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) (AA 138-167), (C-Term) antibody (ABIN1881467) ISCU Antibody (C-term) (ABIN1881467) western blot analysis in mouse lung tissue lysat...
Western Blotting (WB) image for anti-Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) (AA 138-167), (C-Term) antibody (ABIN1881467) ISCU Antibody (C-term) (ABIN1881467) western blot analysis in mouse lung tissue lysat...
Product cited in: Okerlund, Kivimäe, Tong, Peng, Ullian, Cheyette: "Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 12, pp. 4362-8, 2010 (PubMed).

Chan, Zhang, Hemann, Mahoney, Zweier, Loscalzo: "MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2." in: Cell metabolism, Vol. 10, Issue 4, pp. 273-84, 2009 (PubMed).

Kollberg, Tulinius, Melberg, Darin, Andersen, Holmgren, Oldfors, Holme: "Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy." in: Brain : a journal of neurology, Vol. 132, Issue Pt 8, pp. 2170-9, 2009 (PubMed).

Huang, Dizin, Cowan: "Mapping iron s on human frataxin: implications for cluster assembly on the ISU Fe-S cluster scaffold protein." in: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Vol. 13, Issue 5, pp. 825-36, 2008 (PubMed).

Mochel, Knight, Tong, Hernandez, Ayyad, Taivassalo, Andersen, Singleton, Rouault, Fischbeck, Haller: "Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance." in: American journal of human genetics, Vol. 82, Issue 3, pp. 652-60, 2008 (PubMed).