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  • 产品名称：anti-ATP1A3antibody(ATPase,Na+/K+Transporting,alpha3Polypeptide)(AA805-833)

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简单介绍：
anti-ATP1A3antibody(ATPase,Na+/K+Transporting,alpha3Polypeptide)(AA805-833)
详情介绍：
Immunogen This ATP1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-833 amino acids from the Central region of human ATP1A3.
Clone RB42176
Predicted Reactivity Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name ATP1A3 (ATP1A3 Antibody Abstract)
Background The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.

Synonyms: ATP1A3, Sodium/potassium-transporting ATPase subunit alpha-3, Na(+)/K(+) ATPase alpha(III) subunit, Sodium pump subunit alpha-3
NCBI Accession NP_689509, NP_001243142, NP_001243143
UniProt P13637
Pathways Thyroid Hormone Synthesis, Proton Transport, Ribonucleoside Biosynthetic Process
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-ATPase, Na+/K+ Transporting, alpha 3 Polypeptide (ATP1A3) (AA 805-833), (Center) antibody (ABIN1881087) ATP1A3 Antibody (Center) (ABIN1881087) western blot analysis in NCI-H292 cell line ly...
Product cited in: Einholm, Toustrup-Jensen, Holm, Andersen, Vilsen: "The rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site." in: The Journal of biological chemistry, Vol. 285, Issue 34, pp. 26245-54, 2010 (PubMed).

Floyd, Wray, Quenby, Martín-Vasallo, Mobasheri: "Expression and distribution of Na, K-ATPase isoforms in the human uterus." in: Reproductive sciences (Thousand Oaks, Calif.), Vol. 17, Issue 4, pp. 366-76, 2010 (PubMed).

Goldstein, Lerer, Laiba, Mallet, Mujaheed, Laurent, Rosen, Ebstein, Lichtstein: "Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders." in: Biological psychiatry, Vol. 65, Issue 11, pp. 985-91, 2009 (PubMed).