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  • 产品名称：anti-CNR1antibody(CannabinoidReceptor1)(AA161-187)

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简单介绍：
anti-CNR1antibody(CannabinoidReceptor1)(AA161-187)
详情介绍：
Immunogen This CB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-187 amino acids from the Central region of human CB1.
Clone RB41743
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CB1 (CNR1 Antibody Abstract)
Background This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq].

Synonyms: CNR1, CNR, Cannabinoid receptor 1, CANN6
NCBI Accession NP_001153731, NP_001153730, NP_001153698, NP_149421, NP_057167
UniProt P21554
Pathways Feeding Behaviour
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Cannabinoid Receptor 1 (CNR1) (AA 161-187), (Center) antibody (ABIN1881140) CB1 Antibody (Center) (ABIN1881140) western blot analysis in 293 cell line lysates (3...
Product cited in: Van Laere, Casteels, Dhollander, Goffin, Grachev, Bormans, Vandenberghe: "Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 51, Issue 9, pp. 1413-7, 2010 (PubMed).

Monteleone, Milano, Petrella, Canestrelli, Maj: "Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain." in: Journal of clinical psychopharmacology, Vol. 30, Issue 4, pp. 441-5, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Larrinaga, Varona, Pérez, Sanz, Ugalde, Cándenas, Pinto, Gil, López: "Expression of cannabinoid receptors in human kidney." in: Histology and histopathology, Vol. 25, Issue 9, pp. 1133-8, 2010 (PubMed).