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  • 产品名称：anti-CREB3antibody(CAMPResponsiveElementBindingProtein3)(AA66-94)

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简单介绍：
anti-CREB3antibody(CAMPResponsiveElementBindingProtein3)(AA66-94)
详情介绍：
Immunogen This CREB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human CREB3.
Clone RB42213
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CREB3 (CREB3 Antibody Abstract)
Background This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.

Synonyms: CREB3, LZIP, Cyclic AMP-responsive element-binding protein 3, Leucin zipper proitein, Luman, Transcription factor LZIP-alpha, Processed cyclic AMP-responsive element-binding protein 3
NCBI Accession NP_006359
UniProt O43889
Pathways Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded protein response
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 66-94), (N-Term) antibody (ABIN1881228) CREB3 Antibody (N-term) (ABIN1881228) western blot analysis in Jurkat cell line lysat...
Product cited in: Kim, Choi, Choi, Kang, Kim, Lee, Lee, Lee, Kim, Jun, Jeong, Yoon: "HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 20, pp. 3499-510, 2010 (PubMed).

Audas, Li, Liang, Lu: "A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response." in: Molecular and cellular biology, Vol. 28, Issue 12, pp. 3952-66, 2008 (PubMed).