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  • 产品名称：anti-HistoneH2BType2-E(AA12-40),(N-Term)antibody

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  • 产品厂商：半导体
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简单介绍：
anti-HistoneH2BType2-E(AA12-40),(N-Term)antibody
详情介绍：
Immunogen This HIST2H2BE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human HIST2H2BE.
Clone RB41930
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name HIST2H2BE
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

Synonyms: HIST2H2BE, H2BFQ, Histone H2B type 2-E, Histone H2B-GL105, Histone H2B.q
NCBI Accession NP_003519
UniProt Q16778
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Histone H2B Type 2-E (AA 12-40), (N-Term) antibody (ABIN1881418) HIST2H2BE Antibody (N-term) (ABIN1881418) western blot analysis in WiDr cell line lys...
Product cited in: Kim, Guermah, McGinty, Lee, Tang, Milne, Shilatifard, Muir, Roeder: "RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells." in: Cell, Vol. 137, Issue 3, pp. 459-71, 2009 (PubMed).

Pankratova, Manuĭlova, Stepchenko: "[Role of transcription factors s in no-mediated histone H2B promoter repression]." in: Molekuliarnaia biologiia, Vol. 43, Issue 2, pp. 368-73, 2009 (PubMed).

Dai, Yu, Goh, Chng, Tan, Fu, Zheng, Luo: "Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status." in: The Journal of biological chemistry, Vol. 283, Issue 40, pp. 26894-901, 2008 (PubMed).

Zhao, Lang, Ito, Bonnet, Metzger, Sawatsubashi, Suzuki, Le Guezennec, Stunnenberg, Krasnov, Georgieva, Schüle, Takeyama, Kato, Tora, Devys: "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing." in: Molecular cell, Vol. 29, Issue 1, pp. 92-101, 2008 (PubMed).

Kawasaki, Schiltz, Chiu, Itakura, Taira, Nakatani, Yokoyama: "ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation." in: Nature, Vol. 405, Issue 6783, pp. 195-200, 2000 (PubMed).