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  • 产品名称：anti-B-CellCLL/lymphoma9-Like(BCL9L)(AA147-176),(N-Term)antibody

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简单介绍：
anti-B-CellCLL/lymphoma9-Like(BCL9L)(AA147-176),(N-Term)antibody
详情介绍：
Immunogen This BCL9L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human BCL9L.
Clone RB41624
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name BCL9L (BCL9L Antibody Abstract)
Background Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).

Synonyms: BCL9L, DLNB11, B-cell CLL/lymphoma 9-like protein, Protein BCL9-2
NCBI Accession NP_872363
UniProt Q86UU0
Pathways Stem Cell Maintenance
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.37 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 9-Like (BCL9L) (AA 147-176), (N-Term) antibody (ABIN1881110) BCL9L Antibody (N-term) (ABIN1881110) western blot analysis in human placenta tissue ...
Product cited in: Miller, Rutherford, Johnson, Fiedler, Bienz: "Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor." in: Journal of molecular biology, Vol. 401, Issue 5, pp. 969-84, 2010 (PubMed).

Fritzmann, Morkel, Besser, Budczies, Kosel, Brembeck, Stein, Fichtner, Schlag, Birchmeier: "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential." in: Gastroenterology, Vol. 137, Issue 1, pp. 165-75, 2009 (PubMed).

Sampietro, Dahlberg, Cho, Hinds, Kimelman, Xu: "Crystal structure of a beta-catenin/BCL9/Tcf4 complex." in: Molecular cell, Vol. 24, Issue 2, pp. 293-300, 2006 (PubMed).

Brembeck, Schwarz-Romond, Bakkers, Wilhelm, Hammerschmidt, Birchmeier: "Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions." in: Genes & development, Vol. 18, Issue 18, pp. 2225-30, 2004 (PubMed).

Background publications Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).